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KMID : 0352819930090020013
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Kosin Medical Journal
1993 Volume.9 No. 2 p.13 ~ p.22
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Effect of Non-Steroidal Anti-Inflammatory Drugs on n-Formyl-Leucyl-Phenylalanine Induced Migration of Neutrophil
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Abstract
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migration of neutrophil to the inflammatory site is an important phenomenon in inflammatory diseases. To investigate whether non-steroidal anti-inflamma-tory drugs(NSAIDs), which inhibit cyclooxygenase in prostaglandin synthesis pathway, have a
specific
property interfering migration of neutrophil or not, we studied the effects of seven NSAIDs on n-formyl-peptide-induced migration of neutrophil using a 48-well micro chemotaxis assembly.
Oxphenbutazone, phenylbutazone, sulindac, zomepirac and ibuprofen at effective plasma concentration supressed the migration of neutrophil up to 66.4, 33.7, 33.3, 36.2, and 23.5%, respectively. Salicylate showed no effect on the migration of
neutrophil,
however, indomethacin showed stimulation effect. Even though same class of indol dervatives, sulindac inhibits and indomethacin stimuletes the chemotaxis of neutrophil.
From these results, we suggested that there might be another mode ofpharmacological ation of NSAIDs for anti-inflammatory effect, in addition to cyclooxygenase inhibition, direct acting on the chemotaxis of neutrophil.
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